METABOLISM IN FEVER AND CERTAIN INFECTIONS 103 



This calculation is fairly simple. The difference in calories between 

 heat production and heat elimination is divided by the hydrothermal equiv- 

 alent of the body and the resultant is the average body temperature change 

 expressed in degrees centigrade. If, for instance, during a certain experi- 

 mental period the heat production was 100 calories and the elimination 60 

 it would mean the storage of 40 calories in the body. If the subject 

 weighed 70 kg. his hydrothermal equivalent was 58.1 liters of water. 

 40 divided by 58.1 gives 0.68, the degrees C.' that the average body tem- 



EDWARD B. 

 NOV- 6 OCT-27 



12,3, 123 



401 I I :!. 



39 





 38 



c 



37 



CAL 

 100 



50 



HEAT PROD. 



ZIZP 



HEAT ELIM. 



RICHARD T. MORRIS S 

 OCT-18 OCT-24 



123 123 



Fig. 3. Typhoid patients with rising temperature, heat production remaining 

 almost constant and in one case falling. 



perature must have risen during the expirement. Results have frequently 

 indicated that although the rectal temperature usually shows about the 

 same change as the average body temperature there are times when the 

 two differ in extent and even in direction. 



Diagrams have been made showing the heat production and changes 

 in the rectal and average body temperatures of the typhoid patients 

 studied in the calorimeter. (Figs. 2 -to 5.) 



No better opportunity of studying this subject has been afforded, and 

 it seems desirable to devote some space to the analysis of these charts. 

 Most of the patients show a rising temperature because they were studied 

 in the morning and early afternoon. As was pointed out in the original 



