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EUGENE F. DTI BOIS 



even manufacturing fat from carbohydrate fourteen or more hours after 

 the last meal. In the low calory cases the highest quotients were found in 

 the fourth week of convalescence, in the high calory cases in the second 

 week. 



RQ 







Fig. 6. The respiratory quotients of typhoid patients on low diets examined by 

 Kraus, Svenson, Grafe and Roily from 12-14 hours after the taking of food. Fig. 6 

 corresponds to Fig. 1. 



It may be well to mention the fact that several observers have obtained 

 quotients in typhoid fever which depart so far from the normal that we 

 are forced to believe that there was something wrong with the technic. 

 In fact, some of the experimenters on repeating their work with better 

 apparatus have discovered their own errors. The concordance of all the 



Fig. 7. The respiratory quotients of typhoid patients on the high calory diet. 

 Solid squares indicate observations made shortly after meals; open squares, fasting 

 observations; crossed squares, observations made from five to seven hours after the 

 last meal or shortly after a light meal. Fig. 7 corresponds to Fig. 1. 



recent studies has discredited this older work, which, however, is still 

 found in the literature. 



The modern work gives us a picture which can readily be explained. 

 In the early stages of fever the patients who are on low diets rapidly 

 approach the condition of partial starvation, exhausting, more or less 

 completely, their stores of glycogen. For instance, Morris S., on October 

 24th, with a quotient of .76, was deriving 12 per cent of his calories from 

 carbohydrate, 60 per cent from fat and 28 per cent from protein. Patients 



