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EUGENE F. DU BOIS 



tions. Senator has pointed out that the body becomes relatively poorer in 

 protein and richer in fat but the absolute loss of both is so extensive that 

 relative changes are comparatively unimportant. 



There seems to be little or no acidosis in typhoid fever. Ewing and 

 Wolf, who studied toxic patients on low diets, found that the ammonia 

 excretion seldom exceeds the normal figures that would be expected with 



CAL. 

 2000 

 1000 



Fig. 8. Typhoid patient C. B., studied by von Leyden and Klemperer. Although 

 the nitrogen of the food was increased to a high level the negative nitrogen balance 

 persisted. 



subjects who excreted a total of 15 to 25 grams of nitrogen daily. In 

 one of their fatal cases the ammonia ratio reached 8.9 per cent and the 

 output for the day was 2.00 grams. They suggest that the relative lack 

 of acidosis may arise from the pronounced tendency towards the con- 

 sumption of proteins. We can calculate that a nitrogen output of 25 

 grams shows that 81 grams of glucose has been derived from the carbo- 

 hydrate forming portions of the protein molecule. Benedict's starving 

 man derived only one-third as much from this source. We must remember 



