METABOLISM 



FEVER AND CERTAIN INFECTIONS 111 



also that practically all typhoid patients are given some carbohydrates 

 in their food. 



Coleman and Shaffer, who studied patients on high calory diets, found 

 the ammonia excretion was somewhat increased during the active stages of 

 the disease but was not affected by the intake of carbohydrates. They 



Zi Jt Jl JL 



L _1L JO. JL Jl Jl 



V 



Sit 

 49 



47 

 18 

 12 

 6 



1000 



m 



Fig. 9. Morris S. Temperature, body weight. Food nitrogen, continuous line; 

 excreta nitrogen, dotted line. At the base of the chart, columns representing total 

 calories of food. Protein calories, crossed diagonals fat calories, blank carbohydrate 

 calories, vertical lines. The dot-dash line represents the estimated heat production 

 in calories for twenty-four hours. The dashes are placed on days of the observations 

 in the calorimeter. Note that the calories of the food exceed the estimated heat pro- 

 duction except for a period during the first relapse. Food was not measured on 

 December 25th and January 5th. (Coleman and Du Bois, 1915.) 



considered that this was probably coincident with an increased excretion 

 of organic acids but never found diacetic or beta-oxybutyric acid even when 

 the carbohydrates /)f the ration were low. 



Increased acetone has been found by von Jaksch(c) and beta-oxybuty- 

 ric acid by von Noorden(c). 



Protein Metabolism. Over sixty years ago it was clearly demonstrated 

 that protein metabolism was increased in febrile diseases and many ob- 



