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EUGENE F. DU BOIS 



of every grade of severity, perhaps complicated by mixed infections. Obvi- 

 ously it is impossible to make generalizations and say that the metabolism 

 in tuberculosis is thus and so. 



The chemical pathology of tuberculosis was thoroughly reviewed by 

 Ott and his collaborators in 1903, and the chapter on metabolism par- 

 ticularly well treated by May. 



Total Metabolism. Lowy found a considerable increase in the oxygen 

 consumption of a patient with miliary tuberculosis of the lungs but some 

 of his respiratory quotients are so much lower than those found by more 

 recent investigators that there seems to have been some technical difficulty 

 with the methods employed. Grafe, using a respiration chamber, studied 

 12 patients with pulmonary tuberculosis and found the metabolism in- 

 creased from to 50 per cent, with an average of 25 per cent above the 

 normal. In 5 patients with other types of tuberculosis the increases were 

 between 15 and 25 per cent. Holly, in a patient with latent tuberculosis, 

 found an oxygen consumption of 3.9 to 4.9 c.c. O 2 per kilogram and 

 minute, 3.9 being about the average for normal controls. Barbour(c) 



TABLE 9. METABOLISM ix TUBERCULOSIS AS GIVEN BY McCANN AND BARB 



