140 



EUGENE F. DU BOIS 



the investigators who have studied the nitrogen metabolism. Unusually 

 complete analyses were made by Kocher. He found during the febrile 

 periods considerable increase in the excretion of creatinin at the height 



^ DAYS. 



3 4 5 6 7 8 9 10 II 12 13 14 15 16, 17 18 



40 



38' 



N.GM. 

 30 36 



20 



10 



A 



CAL. IN FOOD. 

 2000 



1000 



TEMP. 



r\ 



URFNEN. 



URINE VOL.cc 



CAL. IN MILK. 



FOOD N. 



Fig. 24. Erysipelas patient studied by Loening. The patient was first taken ill 

 with facial erysipelas on April 20th and did not become fever-free until April 27th. 

 On April 30th he had a relapse. This metabolism experiment began on May 3rd. 

 The diet consisted exclusively of milk. Note that the nitrogen excretion curve fol- 

 lowed the temperature in the first and third relapses but showed a considerable lag 

 or epicritical rise in the second relapse. 



of the disease reached 2.4-2.6 gm. per day, the uric acid 0.8-2.0, and 

 the ammonia 1.8-3.0. Mohr has found that the C/N" ratio in the urine 

 is within the normal limits in erysipelas as in other fevers. 



Metabolism in Malarial Fever 



Total Metabolism. It is difficult to give figures which will represent 

 the total caloric output of a patient with malaria since the heat produc- 

 tion which is practically normal during the afebrile periods may be 200 

 per cent above normal during the chills. Numerous studies of the heat 



