DISTURBANCES OF CARBOHYDRATE METABOLISM 303 



other, dried and weighed. One part nmcic acid represents 1.33 parts 

 ga lactose. Whether originally free or combined must be determined from 

 a comparison of the reduction, polarization and inucic acid yield. 



Other Melliturias 



Maltosuria. Maltose has frequently been supposed to be present in 

 diabetic and other urines. But the evidence therefor is quite unsatis- 

 factory. Geelmuyden(6) attempted to separate maltosazone by frac- 

 tional crystallization of the osazones from diabetic urine. He obtained 

 from the more soluble fraction crystals melting between 192 and 207. 

 Since glucosazone melts at 205 and maltosazone at 202-208, it is 

 evident that the melting point will not serve to distinguish them. Geel- 

 muyden claimed that crystals having this high solubility were not obtained 

 from glucose, and that they could be isolated from mixtures of maltose and 

 glucose only when the former constituted 10 per cent, or more, of the mix- 

 ture. But it is quite possible that some urinary constituent increased the 

 solubility of some of the glucosazone. It is unfortunate that Geelmuyden 

 did not control his procedure by means of experiments with glucose added 

 to normal urine and that he did not identify the maltosazone in some other 

 way. Maltosuria was also reported by von Ackeren in a case of carcinoma 

 of the pancreas, and by Rosenheim in a case of chronic pancreatitis, but 

 their evidence is similarly insufficient. Rosenheim did, indeed, determine 

 the nitrogen content of the osazone, but he did not present details and 

 figures so that it is impossible to judge of the accuracy of his interpreta- 

 tion of his results. The importance of having all the data will be more 

 evident presently. 



Lepine and Boulud(a) reported the presence of maltose in the urine of 

 a diabetic, and in that of a depancreatized dog. The claim is based entirely 

 upon the difference between the values obtained by polarization and by 

 reduction methods, and the disappearance of this discrepancy upon 

 hydrolysis with hydrochloric acid. But examination of their figures 

 shows that these were not identical after hydrolysis. Moreover, in a 

 control experiment with 10 grams of maltose and 40 grams of glucose, 

 the values they obtained before hydrolysis were 63 grams by rotation, 

 which is approximately the calculated quantity, and 31.64 grams by reduc- 

 tion. The calculated equivalent is about 46 grams of glucose. After 

 hydrolysis, the values they obtained were 40.5 grains by rotation and 35.2 

 grams by titration. The calculated value is 50.28 grams for both. What 

 became of about 15 grams of sugar is not indicated. Kottmann's report 

 is similarly discredited. 



A report that carries more weight is that mentioned by Neuberg(J) 

 (1911) of a case observed by Magnus-Levy. The urine showed a marked 



