320 



HERMAN O. MOSENTHAL 



TABLE 3 



ANALYSIS OF NORMAL AND NEPHRITIC HUMAN MUSCLE. (Mosenthal, Hiller and Clausen, 



unpublished) 



towards the end of life in renal disease and presumably indicates the ex- 

 istence of accelerated protein destruction (see ereatin in nephritis). The 

 amino acids apparently remain unchanged throughout the course of the 

 disease (see amino acids in nephritis). The greatest actual and propor- 

 tional rise in the non-protein nitrogenous constituents in the blood occurs 

 in the urea which under normal conditions constitutes about 50 per cent 

 of the total non-protein nitrogen, while when the kidneys become unequal 

 to fulfilling their task it goes up to between 80 and 90 per cent (see the 

 relation of the urea to the total non-protein nitrogen of the blood in ne- 

 phritis). 



Bearing these facts concerning the blood in mind, the examination of 

 the tissues becomes of importance. It is very essential to know whether 

 by analyzing the blood an adequate conception if what is occurring in the 

 other parts of the body may be obtained. The tissues might retain more 

 or less of the non-protein nitrogenous materials than the blood. Foster(fr) 

 (1919) has shown that the total non-protein nitrogen in the tissues rises as 

 it increases in the blood. From Table 3 it may be seen that the most 

 marked rise occurs in the urea nitrogen, that there is a distinct increase in 

 the creatinin and no change in the amino acid nitrogen. Thus the blood 

 and tissue changes may be considered as paralleling each other very 



