METABOLISM IN NEPHKITIS 



329 



TABLE 12 



CBEATIN VALUES OF BLOOD COMPARED WITH THOSE OF SOME OF THE OTHER 

 NON-PROTEIN NITROGENOUS CONSTITUENTS. THE INCREASE IN BLOOD CREATIN OC- 

 CURS ONLY WHEN RENAL INSUFFICIENCY is FAR ADVANCED; IT DOES NOT PARALLEL 

 ANY OF THE OTHER SUBSTANCES. (Mosenthal, Hiller and Clausen, unpublished) 



is due to nephritis ; it may be caused by the partial or complete starvation 

 which these patients are unavoidably subjected to. 



In the voluntary muscle, creatin does not rise as renal insufficiency 

 develops. This may be seen in Table 13. The figures for urea N in 

 the parallel column indicate that the excretory function of the kidney 

 has been definitely curtailed and yet the creatin values are not always 

 above normal. In those instances in which the creatin is raised the 

 urea N is not necessarily increased. These observations bear out what 

 has been noted in the preceding discussion of the significance of creatin 

 in the blood, namely, that the rise in blood creatin, while associated with 

 renal insufficiency, is not caused by it, but is brought about by protein 

 disintegration. The comparatively low creatin content of nephritic 



TABLE 13 



CREATIN CONTENT OF MUSCLE IN NEPHRITIS. IT DOES NOT USUALLY RISE ABOVE 

 THE NORMAL LEVEL, EVEN THOUGH THERE is MARKED RENAL INSUFFICIENCY AS 

 INDICATED BY THE FIGURES FOR UREA N. (Mosenthal, Hiller and Clausen, unpub- 

 lished.) 



Mg. per 100 gm. Muscle 



