498 



JACOB ROSENBLOOM 



TABLE XII 

 EXCRETION OF BENCE-JONES' PROTEIN DURING TWELVE-HOUR INTERVALS IN CASE 3 



V. Bonce-Jones* Protein and Multiple Myeloma 



Myelopathic Proteosuria (Kahler's Disease). In 1889 Kahler and 

 Huppert reported a case of multiple myeloma from clinical and chemical 

 standpoints, respectively, and in 1897 Bozzola reported a case under the 

 title of "Sulla Malattia di Kahler," thus recognizing Kahler as the first to 

 show the relationship between proteosuria (so-called) and primary bone 

 disease. The lesions, however, were classified in 1873 as myeloma by von 

 Rustizky. 



Careful study of cases of Bence-Jones' proteinuria shows that there 

 must certainly be some relation between the excretion of Bence-Jones' pro- 

 tein and diseased conditions of the bones. Although we cannot say that 

 Eence-Jones' protein is peculiar to the growth known as multiple myel- 

 oma, 1 it is certain that Bence-Jones' protein is present in the urine in 80 



1 Various names applied to multiple myeloma: Myeloma multiplex (Rustizky), 

 sarcoma multiplex ossium (Buch), pseudoleucemia myelogenes (Runeberg), osteo- 



