ALKAPTONURIA 505 



DimetKy\ pentisvc DimctU 

 n ' UU .cMof 



Ac\<l 



Osborne synthesized homogentisic acid by condensing hydroquinone 

 dimethyl ether with ethyl monochloracetate in carbon disulphid solution 

 by means of aluminium chlorid and removing the methyl groups from 

 the resulting ether by amorphous phosphorus and hydriodic acid : 



o 



