ALKAPTONTJRIA 



509 



o- and m-tyrosin, but also for the ortho- and metaoxyphenyl pyruvic acid, 

 according to Neubauer. 



CHNH 

 J 2 

 COOH 







OH 



CH. 

 I " 



CHNH 



I 



2 



COOH 



COOH 



COOH 



P o s n 



r ost n 



The paratyrosin and the parapyruvic acid will influence the alkapton 

 excretion. 



It was Erich Meyer(a) who first suggested that the para-oxy group is 

 rather a necessity in the change from p-tyrosin to alkapton, and that the 

 change takes place by a shifting of the side chain rather than by a move- 

 ment of the OH radicals. 



Neubauer suggested that the transformation of the a-amino acids 

 in the body takes place through an intermediary a-ketone acid as follows : 



p. Tyro %tn 



CH.CO.COOH I |CH .COOH 



HO CH .CO. COOH 



2 



IHyclroqui 



1 



unone 



Homooe-ntisic <XC1<1 



