526 



KAHN AND ROSENBLOOM 



TABLE SHOWING DAILY EXCRETION OF CYSTIN IN 20 CASES OF 



CYSTINURIA 



Hole found that the daily elimination of cystin was 0.3 to 0.5 gm. 

 The amount of cystin in urine varied with the change in diet, but the 

 variation is not proportional to the total sulphur or total nitrogen. In 

 one case the administration of cystin per os was completely excreted as 

 sulphate. Cadaverin was found only once in the urine. 



That cystinuria is due to some defect in the intermediary metabolism 

 of amino-acid is shown by the fact that van Amstel has described a case 

 of alkaptonuria and cystinuria in the one patient. 



Abderhalden and Schittenhelm found leucin and tyrosin in the urine 

 of a cystinuric patient a man, 34 years of age, who came from a 

 healthy family. The patient was suffering from frequent attacks of 

 cystic calculi. The urine was light yellow and quite clear. Upon stand- 

 ing the typical six-sided crystals of cystin separated. The reaction of 

 the urine was acid, and occasionally it showed traces of protein. The 

 daily urine excretion was 2000 to 2500 c.c. of a specific gravity of 

 1.012 to 1.015. Moreigne(a) (&) had also found these nitrogenous bodies 

 in the cystinuric. 



