CYSTINURIA 



529 



of Loewy and Neuberg, that cystinuric individuals are unable to oxidize 

 ingested cyst in. 



Simon(&) also found that after feeding of tyrosin and leucin he could 

 not obtain it in the urine ; Gross and Garrod confirmed Simon's findings. 



Several observers have noticed the occurrence of rheumatic diatheses 

 in the cystinuric. Marowsky found cystin in the urine in a case of liver 

 disease. In a case of syphilis Ebstein found cystin in the urine which 

 he cured by treatment with mercury. Of course it must be borne in 

 mind that Baumann and Preusse and Jaffe have caused artificial cysti- 

 nuria by feeding the halogen benzols together with ethylcystin. 



According to Wolf and his collaborators (Marriott, Williams, 

 Shaffer), both cystein and cystin prepared from patient's urine were 

 likewise oxidized when given by mouth. The cystin excreted in the 

 urine is evidently not absorbed as such from the intestine, but must be 

 absorbed in the form of a larger molecule; because cystin absorbed as 

 such is oxidized. 



They found that an increase of food protein leads to an increase of 

 cystin excreted, but when the food protein is hydrolized outside the body 

 and isolated cystin is given to a cystinuric patient, the sulphur of the 

 cystin is oxidized to sulphuric acid. 



Cystin injected subcutaneously was excreted in the form of neutral 



