592 SAMUEL H. HURWITZ ' 



In experimental posthemorrhagic anemia, Gies found a definite rise 

 in the total urinary sulphur, which corresponded well with the increased 

 protein catabolism. Wide fluctuations in the elimination of sulphur have 

 been noted in chlorosis. For neutral sulphur, Schmidt's values range 

 from 13 to 23 per cent and Vannini's from 13 to 26 per cent of the 

 total sulphur. The results of the latter observer indicate, on the whole, 

 the existence of some parallelism between sulphur elimination and nitro- 

 gen excretion. 



The figures for the excretion of ethereal sulphates in chlorosis have 

 been found relatively low by most workers (von Noorden, Vanriini). This 

 is of interest in connection with the view of some observers concerning 

 the presence of excessive intestinal putrefaction in chlorotic patients. 



Sulphur metabolism in the hernolytic anemias has been little studied, 

 especially by recent workers. From the available contributions, it U 

 apparent that great fluctuations in the elimination of sulphur compounds 

 may exist in these conditions. In severe forms of anchylostomiasis ane- 

 mia, Schupfer arid Ue Rossi (a) noted high values for neutral sulphur, in 

 some instances amounting to twice the normal figure. The results, how- 

 ever, obtained in patients with primary pernicious anemia have been quite 

 variable. Thus both of the patients studied by Schmidt showed an in- 

 creased output of neutral sulphur and a normal or relatively low excre- 

 tion of ethereal sulphates. Von Moraczewski, on the contrary, obtained 

 practically normal figures for neutral sulphur and strikingly low outputs 

 of ethereal sulphates in his carefully studied pernicious anemia patients. 

 Similar results have been found by Denis(d), who further demonstrated 

 that spleriectomy produces no appreciable change in the excretion of sul- 

 phur. 



Concerning sulphur metabolism in congenital hemolytic icterus, only a 

 few observations exist in the literature. So far as can be determined, 

 the complete metabolic study of McKelvy and Rosenbloom give the only 

 valuable data for sulphur metabolism in this disease. Their patient 

 lost 1.88 grams of sulphur in a period of five days, a loss which paral- 

 leled somewhat the increased elimination of nitrogen, And except for 

 the marked increase in the excretion of ethereal sulphates on the first 

 and last days of the metabolism experiment, which they attributed to 

 intestinal putrefaction, the partition of urinary sulphur was found normal. 



The observations on the excretion of sulphur compounds in leukemia 

 are also few in number. From the available studies, it appears on the. 

 whole that the total quantity of sulphur present in the urine of leukemia 

 patients is approximately proportional to the amount of nitrogen ex- 

 creted (vori Moraczewski (c), Taylor(6)(A. E.), von Stejskal and 

 Erben(a)). 



Chemical Changes in the Nitrogenous Metabolites and Fats of 

 the Blood. Up to the present time comparatively little application has 



