PATHOLOGICAL METABOLISM OF THE BLOOD 605 



circulating leukocytes derived from this tissue (Selling(a) (&)). As a re- 

 sult of these destructive changes, derangements of- metabolism have been 

 found, which, however, have been too little studied to make possible any 

 definite conclusions concerning them. In some observations on three 

 healthy individuals and on one leukemic patient, Sohn noted a reduction of 

 the oxidative processes of the body. He found an increased output of 

 neutral sulphur and -ammonia, and a diminished percentage excretion of 

 urea met;Tbolic changes which have been observed also in other severe 

 intoxications. The uric acid elimination remained "normal notwithstand- 

 ing the great destruction of white blood-cells due to the leucotoxic action of 

 benzol. 



Dori, in a similar case, studied over a period of fifty days, determined 

 the influence of benzol upon the excretion of nitrogen, creatinin and 

 creatin. During the period of observation, the patient showed constantly 

 a negative nitrogen balance, and an increased output of creatin and crea- 

 tinin. The elimination of creatin was especially significant, and in view 

 of the known relationship which exists between the elimination of creatin 

 and endogenous protein metabolism, Dori is inclined to regard the in- 

 creased creatinuria as the result of a toxic action of benzol on the body 

 protein. 



