7Y8 FEANCIS H. McCRUDDLN 



which, according to Pemberton, follow administration of diets in which 

 protein and carbohydrate are restricted in quantity, and replaced in part 

 by fat. During the war Pemberton studied different phases of the metab- 

 olism in a number of cases of chronic rheumatism (Pemberton and Robert- 

 son, Pemberton and Tompkins, Pemberton and Foster, Pemberton and 

 Buckman). He found no change in the basal metabolism or in the metab- 

 olism of protein, fat, or carbohydrate so far as disclosed by studies of 

 the respiratory exchange. The urea, non-protein nitrogen, carbon dioxid 

 combining power, calcium, fat, cholesterin, and glucose of the blood were 

 within normal limits. He found that the blood creatin is occasionally a 

 little high. He found, likewise, that after administration of glucose the 

 blood sugar rises higher than it does normally after similar dosage, and 

 returns to the starting level more slowly than in normal persons. He 

 found no marked abnormality in renal function. 



Chronic rheumatism, or, at any rate, certain forms of chronic rheu- 

 matism and gout have always been supposed to be closely related. And 

 the belief is widespread that the chronic arthropathies are the consequence 

 of a disturbance of the purin metabolism. But the experimental evidence, 

 published up to now, indicates no marked deviations of purin metabolism 

 from the normal (Ackeroyd(fr), Mallory(&)). 



