874 



JOHN E. WILLIAMS 



stimulant to the kidneys. He stated that the power to concentrate urine 

 does not decline in patients who suffer with the disease for years. Ebstein 

 (g) was of the opinion that the disease is of nervous origin and that poly- 

 uria is a consequence of thirst. Meyer (fe) concluded that the polyuria was 

 due to a lack of power of the kidney to concentrate urine. Fitz studied by 

 the newer methods of investigation the problem of kidney function in his 

 case and concluded that there existed a hyposthenuria due to the hypersen- 

 sitiveness of the renal vessels and that polyuria resulted from the diuretic 



Infan-_ 

 dibulum 

 Ant. lobe- 

 hypophysis 



Post lobe- - 

 hypophysis 



Maznmillarts 

 body 



- -Optic 

 chiasm 



Oculomotor 

 nerve 



Tuber 

 cineretim 



Interpedun- 

 cular fossa 



\---Pons 



Fig. 6. Diagram of ventral surface of brain in region of hypophysis. Shaded 

 area shows portion of brain involved in the production of the clinical syndromes of 

 disturbed vision, acromegaly and giantism, dystrophie adiposogenitalis and diabetes 

 insipidus, as indicated by the legend of Fig. 5. 







properties of the sodium chlorid. The concentrating power of the kidney 

 was not entirely lost. Meyer, Fitz(d), and Leschke have shown that when 

 extra salt or urea is added to the diet, they are eliminated in the urine. 

 They are concentrated to a greater degree in the urine but more water is 

 needed to eliminate them. Other salts by way of compensation are con- 

 centrated to a lesser degree. Polyuria, therefore, is a result of ingested 

 salt and an inability of the kidneys to concentrate it to any amount in the 

 urine. In this connection it would be interesting to know the relative 

 proportion of sodium chlorid to total blood solids. Since the concentration 

 of chlorids in the blood plasma is fairly constant any absolute increase of 



