DIABETES INSIPIDUS 



879 



Curves of Two Hour Renal Studies on a Case of Diabetes Insipidus Showing 



the Concentration of Total Solids, Nitrogen, and Chlorids before 



and after the Injectio-n of Pituitrin 



1025 

 1020 



1016 

 1010 



loos 



. % 



1.20 

 0.84 

 0.48 



0.32 



0.08 



Hitroeen 



Sodiun Chloride 



*rlode 7-9 9-11 11-1 1-3 3-5 



5-7 



7-9 9-7 



Solid line - curves of studies without pituitrin. 

 Broken line- curves of studies with one cubic centimeter 



of pituitrin injected subcutaneously at 



9 A. II 



Fig. 7. It will be observed that on the day when pituitrin was not given, the 

 specific gravity of the urine during the various two hour periods ranged from 1.006 

 to 1.008. On the days when pituitrin was used, during the second period, it rose to 

 1.025 and there persisted for the next two periods after which it gradually began 

 to fall, reaching 1.007 on the following morning. The per cent of nitrogen followed a 

 similar course. On the day when no pituitrin was given, its range of concentration 

 was from 0.15 to 0.39 per cent; while on the day pituitrin was given, the range 

 was from 0.13 to 1.26 per cent. After the third two hour period, it began to fall 

 gradually, reaching the low level by the next morning. The concentration of chlorids 

 estimated as sodium chlorid gave similar curves. In brief, without pituitrin there 

 is marked fixation of specific gravity and nitrogen and sodium chlorid concentration. 

 Pituitrin enables the kidneys to concentrate for fifteen to twenty hours at a normal 

 rate total solids, particularly nitrogen and sodium chlorid. 



kidney function in his case, using the two-hour renal method of Mosenthal. 

 While on a test diet containing approximately 85 grams of protein and 5 

 grains of added salt, two-hour renal studies were made with and without 

 pituitrin administration. The day period in each test began at 7 A. M. 



