880 JOHN R. WILLIAMS 



and ended at 9 P. M., the night period began at 9 P. M., ending at Y o'clock 

 the next morning. The patient was allowed to drink water as desired. 

 The following is a summary of the important facts observed in the two 

 tests. 



A study of the table on page 878 and the accompanying curves, Figure 

 7, indicates clearly the following conclusions. 



1. Before the administration of pituitrin, the patient had a very 

 severe thirst throughout the entire 24 hours. After its administration, 

 thirst was noticeably less, no water being taken during the night. 



2. Before pituitrin administration, large quantities of urine of low 

 specific gravity were voided every two hours during the day. After its 

 administration, small amounts of high specific gravity were passed. In 

 both tests a large amount of urine of low specific gravity was voided during 

 the night. 



3. Before pituitrin administration, the nitrogen concentration in the 

 urine was very small and quite uniform; after pituitrin, the concentration 

 was much higher and more variable. 



4. Before pituitrin administration, the sodium chlorid concentra- 

 tion in the urine was also very small and fixed; after, the concentration 

 was much greater and more variable. On the same diet, almost twice as 

 much of this salt was eliminated before as after the use of pituitrin. 



5. The action of the pituitrin is most intense immediately after ad- 

 ministration and progressively declines so that by the end of the 24 hour 

 period its action has disappeared. 



