GENERAL INDEX 



777 



Insuffisance pluriglandulaire, of Claude 

 and Gougerot, pathology and patho- 

 genesis of, ii, 891. 



progress of, ii, 889. 



symptomatology of, ii, 888. 



therapy in, ii, 891. 



Internal secretion of the testes, See 

 Testes, internal secretion of. 



Internal secretions, action of, on cen- 

 tral nervous system, i, 76. 



classification of, as autocoids, i, 4. 



as erregende and hemmende, i, 5. 



hypertensive and hypotensive, i, 5. 



conditions determining, i, 10. 

 chemical, i, 11. 



demonstration of presence of ac- 

 tive principles, i, 11. 



histological, i, 10. 



physiological, i, 11. 



history of, accepted view of, enun- 

 ciated by Johannes Miiller, i, 57. 



acromegaly or gigantism, i, 55, 56. 



action of, on central nervous 



system, i, 76. 

 Addison's disease, i, 55. 



Addison's monograph "On the 



Constitutional and Local Effects of 

 Diseases of the Suprarenal Cap- 

 sules," i, 54. 



antispasmodics, i, 49. 



Brown-Sequard in 1891, i, 62. 



carbohydrate metabolism, i, 63. 



correlation with the sexual func- 

 tion, i, 69. 



discovery of Claude Bernard 



(1849), that temporary glycosuria or 

 medullary diabetes mellitus may be 

 produced by puncture in region of 

 fourth ventricle of the brain in the 

 dog, i, 59. 



glycogenic function of liver, 



Claude Bernard (1843), i, 58, 59. 



iodothyrin in body, suggesting 



relation of thyroid gland to iodin 

 metabolism, i, 63. 



pancreas possesses an internal 



secretion as well as a digestive func- 

 tion, i, 63. 



parathyroids and calcium me- 

 tabolism, Ivar Sandstrom (1880), i, 

 63. 



"dystrophia adiposogenitalis" of 



Frolich, or pituitary obesity, i, 53. 



exophthalmic goiter, i, 51. 



experiment of A. A. Berthold 



(1849), in transplanting testes of 

 fowl to another part of its body, i, 

 57, 



Internal secretions, history of, Ber- 

 thold's experiment, Brown-Sequard 

 (1856), in producing Addison's dis- 

 ease by removal of suprarenal cap- 

 sules, i, 60. 



-Brown-Sequard (1889), on re- 

 juvenation by administration of tes- 

 ticular extracts, i, 62. 



-E. Frank (1912) and Harvey 

 Gushing (1913) that there is a poly- 

 dipsia and polyuria deriving from 

 the pituitary body, i, 59. 



-Mering, von, Joseph (1886), 

 producing experimental diabetes by 

 ingestion of phlorizin, i, 63. 



-Minkowski, Oscar (1889), pro- 

 ducing experimental diabetes by ex- 

 cision of pancreas, i, 63. 



pineal gland, extirpation and 

 feeding and injection experiments, i, 

 68. 



removal of pituitary body, par- 

 tial and total, i, 65. 



first crude elements of therapy of, 

 i, 47, 48. 



first discovery regarding effects 

 of absence of thyroid body, i, 52. 



first experiment in physiological 

 surgery upon human beings, i, 66. 



first half of nineteenth century, 

 i, 57. 



function first stated clearly by 

 Theophile de Bordeu (1722-76), i, 

 46. 



glycogenic secretion in animals, i, 

 58. 



hormonic equilibrium of body 

 and thermodynamic equilibrium, i, 

 76. 



investigations and treatises on, i, 

 77, 78. 



lungs or individual cells of body 



tissues provisionally regarded as 

 ductless, glands, i, 58. 



myxedema, i, 53. 



-observations of Claude Bernard, 



epoch-making character as indicated 

 by Sir Michael Foster, i, 60. 



(1843) introducing new 



concept of, i, 58. 



Brown-Sequard on old Bordeu 

 theory of (1893), i, 62. 



chromafin system, epinephrin, 

 i, 68. 



chromaphil system, i, 68. 



endemic goiter, in antiquity, i, 

 50. 



giants and dwarfs, i, 49, 



