EFFECT OF ALCOHOL ON TRYPSIN DIGESTION 29 



In this case the function is the same (hydrolysis of a protein to. form simpler 

 products), but it would seem that different side chains may be necessary for 

 the hydrolysis of different proteins. 



Summary. 



Alcohol when present to the extent of 3 % and upwards markedly inhibits 

 the action of trypsin on fibrin. The digestion of caseinogen by trypsin is not 

 affected until the concentration reaches 10 %. The action of alcohol is not 

 due to the destruction of the trypsin, since on suitable dilution of the mixture 

 of trypsin and alcohol the digestion of fibrin is as great as in the control. 



Fibrin is not rendered less digestible by contact with dilute alcohol, but 

 seems to be slightly more readily dissolved by trypsin than previously. 



If "trypsin" is a single enzyme the digestion of fibrin and caseinogen is 

 probably carried on by different side chains, those digesting fibrin being 

 much more readily affected by alcohol than the others. 



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