Under normal conditions the amounl of NaHCO 



constant (amounting to 50-65 vols, per cent < ivhen 



it indicates thai an excess of fixed acid musl !><• p 



by Van Slyke and others to constitul nition * — 



namely, fl a condition in which the concentration of bia in th*» 



blood is reduced below the normal level." I 



for any reason should no1 respond promptly enough to an ii in 



the molecular ratio , . and <\ nsequently l 



condition is called uncompensated acidosis, but if the center »nd 



m> that Ch is Ik'M constanl although NaHt 1 1 condition 



is .ill.' Of ' "//'/" flSati '/ acidosis. 



For practical reasons, therefore, the study of pathological acidoe 

 pends on an estimation of the bicarbonate content of the bl< 

 it is simpler to carry oul and is of equal valui plasma. \V 



plasma is obtained by removing 1>I 1 from a vein of the arm and c 



trifuging immediately oul of contacl with air (so thai CO, i aol be 



lust from it it contains approximately 60 vols, per cent I (l 



we know that the partial pressure of CO, in M 1 is equal to 42 mm. Hg 



scertained from determinations of the alveolar ' set 14), 



we can calculate how much of the 60 vols per cent must be in simple 

 solution by application of the law of solution of gas in a liquid 

 336). It has been found thai plasma at body temperature and at 

 mm. Hg atmospheric pressure dissolves 0.54 ... bo thai 



42 

 12 mm. it will dissolve =^x 100x0.54 I vols 1 nbing 



[H,CO 1 



the figures to our equation we 



NfaHCO 

 This definition of acidosis leaves oul 1 all conditions thai m 



raise the ratio v the addition of U.CO, wit mp BinR 



\all< ( > 



any of the NaHt It > . such, for exampl< 



carbonic acid is presenl in the blood plasu 



l i i are nol infrequenl in both health and dis< 



ditions the above definition ie sufficiently <-<>u W 



we come to Btudy th ntrol of the respiral 



an increase in the ratio v ,, 



actual increase in «',, ran be produced bj eaush 



• n ii 



\.iiieO» K , 



1 1 . 

 K .i ■ : j 



