in 



igulation, which it do< do, ho 



to 80 ' and filtered i '■ 

 antagonistic action ia quantitative in tl. 

 the peptone-plasma inhibits the actio 



>urce of antithrombin in the bodj ap] 

 the liver, for it has been found: I thai pept» 

 from which the liver has been removed doe 

 be formed I tenney and Minol 2 thai pe] 



portal vein cans.- antithrombin to appear in tl 

 idly than when the injection ia made into a 

 when the liver ia perfused outside the b( ith a : 



taining peptone, antithrombin accumulates in 



A fluid containing a high 

 by the Bo-called salivary gland at the head • 

 tion of tin* fluid ia to prevenl clotting of tl 

 may continue to such it withoul intei 

 ing leechea for medicinal purposes it is I 



and thoroughly with water bo thai all tri 

 be removed; otherwise the bleeding may continm 



Practical use ia made of this effecl of the 1 h t(» pr 



outside tlif body, or it may be used to inhibit c 



experiments where <-l<»ttiiii_ r would othei with t ; 



- : for example, in < ■ i circulation • 

 experiments in vividiffusion 7 l 



head ia cul off and extracted either with - 

 chloroform, which ■ other proteina from th< 



in<; a strong antithrombin, known under 

 At temperaturea aboul thai of the body the acti 



itly augmented. In animals li] mammals in \vl 



of antithrombin is small, this ma> be in 

 idity <>f the blood Howell Blood contj 

 made t" '•!<•) 1>\ the addition <>t' thrombii 



