BLOOD CI/) 111 



may cause al Brs1 a prolongation at 



'I'h. iilta b ith larger do • related to 1 1 



repeated doses of relatively large amounts nephrine in nay 



v.. greatly retard coagulation aa to make the animals p emo« 



philic. It was further found b) Cannon and hi eph 



rine doea not influence the clotting time when injected int< 



from which the abdominal viscera have been r< n 



by ligation i>t' the inferior vena cava and the abdominal In tl 



of the influence which destruction of liver cells 



form, etc. is known t<> have in lengthening clottii ould -■ 



reasonable to i lude that it must be through th 



rine develops its clotting effect 



Stimulation of the splanchnic nervet l i 



and it would appear thai this action depends on the resulting li 

 cretion of epinephrine (page 746 for it is n Mowing stim 



tiuii of the nerves in animals from which the adr< 

 excised Cannon and Mendenhall). The interesting n is m 



by Cannon that the Bhorter clotting time observed in animals 

 Btrong emotions of frighl or fear may also I"- due to th< 

 of epinephrine which this worker believi 



Blood Clotting in Disease 



With the factors concerned in the process - i>i»'-d in n 



not surprising thai the underlying causes respoi Bible for d< 

 ficienl clotting of l»l<» ( >d in diseased conditions 

 intravascular clots thrombi are little understood. H 



ell's theory "i" the nature of the process, which is tl 

 the presenl time, abnormal clotting mighl be due 

 causes: I .1 diminisht <l amount I 



hepatic n-lls are greatly damaged, as in : 

 phosphorus and in Buch dis< ite yellow 



fever. In man} cases of chronic cirrhosis >>r the l 

 have shown, the blood also clol 

 It Bhould be pointed oul thai it is no1 s,, much th< 

 increased in Buch c as the tin I 'hat 



is affected. 



I ncy in /" '. In th nditinn 



neonatorum," undoubted benefil is d- 



ut* hi 1 Berum or h> din el blood I 



bin <>r prothrombin is thus fun 



i Since tl 



In.th blood cells and tissue cells, il d<>< 



