corpuscles, « hich appear in 

 ditions. A similar inci i 

 rhagic anemia, the rat elation 



regeneral ion of the red corp 



The Mechanism by Which the Demands oi the Tissues for 



Oxygen Are Met 



There are two possible methods bj w i 

 I i... a chai -•• in the < 

 the plasma, bo thai the hemoglobin m< 

 of < >_ : and 2 by an inc 



the 3 of tin' act i' 



Regarding the firsl of these possibility 

 are produced during metabolism of acting tis 

 when muscles contracl in tl 

 produced in large amounts, and when the 

 Barcolactic acid. In the submaxilL -i j...s- 



show that the Ch of the venous bl 1. as m< 



the dissociation curve of hemoglobin, becon 



ing glandular activity. Thai this increase in I 



aln-ady seen As to the 



in temperature and in saline constitui i at 



presenl be said. 



Regarding the second possibility, 



either upon the action <>n the hi I 



along vasomotor nerves, or upon tl 

 vasodilating or depressor subst 



has 1 ii accumulal ing in recenl ; 



depressor substances are produced, and I 

 2 organic bases of a similar 

 mine . This latter subst; 

 cause of its close relationship t<> 

 protein molecule namely, histidii 

 ducing \ asodilatation is exl rao 

 drug injected intravenously inti 

 pressure bj fifty i" 



Bui bi such an h> p< 



show that, independently • 



hi may dilate Tl 

 effe< • stimulating w itl 

 the submaxillan 



