THE METABOLISM OF THE CABB0HYDBA1 



T s Grams of the Various Amino Bodies Were Gives 

 Phlorhizin-diabetio Da 





It is of further interest to point out that these four amino acids 

 constitute about 26 per cent of all the amino acids in flesh protein, and 

 that the total yield of glucose from them could be 26.3 grams; thus 

 accounting for uearly one half of the 66 grams which a diabetic animal 

 produces i'rom 100 grams of flesh. 



Gluconeogenesis in Normal Animals.- Although it has been clearly 



shown by the indirect method that uo1 only protein bul its d mp 



tion products as well, can be readily converted into glucose, yet this does 

 not aecessarily indicate thai a similar conversion occurs in the nondia- 

 betic animal. That such is the case, however, can be shown in various 

 way- Thus, at the end of a period of long starvation a lerable 

 quantities of glycogen are quite commonly found in the body, and the 

 blood Bugar, although lower than normal, never entirely disap 

 Now, since no carbohydrate is being b - ; . and the body s "his 



foodstuff become exhausted early during starvation (cf. pag . it 



vident that the carbohydrate must be produced from the protein of 

 the animal's body. A still mor< avinci perimenl can be con- 



ducted by producing strychnine convulsions in a starving animal. I 

 the animal is killed after the convulsions have Listed for a certain time, 

 the tissues will be found almost if not entirely fr< gen, 



bul it' the convulsions arc made to disappear by giving chloral and the 

 animal allowed to sleep for some time before killing it. glycogen again 

 accumulates in the body. This glycogen musl l.a- n manufactu 



out of noncarbohydrate material. 



i orroborative evidence of :i somewhal different nature is furnished by 



