I 'AT METABOLISM 





od Lipoids • in Di 



Fat by Bloor'a I 

 Method I 



rotal Fatty AcidsJ 



Lecithin 



Cholesterol 



< ;]\ cerides 

 Total Lipoids 



Whole Bl 1 



Plasma 



Whole Blood 

 ma 



puscles 



Whole Bl l 



Plasma 

 < 'in puscles 



Whole Bl 1 



Plasma 

 puscles 



Plasma 

 Corpuscles 



Plasma 



m a r. 

 i-i i: ' 



0.62 



0.37 



0.34 



0.42 



0.22 

 0.23 



0.20 



0.10 

 0. 



0.68 



Mil. I) 

 DIAB1 



0.83 



' 

 0.64 



0.32 

 0.24 

 0.42 



0.24 

 0.21 



g 



0.18 



DIAB1 



L.06 



i 



0.46 

 1.16 



l-I \!:i 



1.41 

 L.80 



1.0] 

 1.28 



0.40 



0.41 

 0.51 



- 



S 



It will be observed thai there i- about <».7 per cent of total fatty bud- 

 stances in norma] blood. The fatly acids (palmitic and oleic) amount to 

 aboul 0.4 per cent, and arc equally distributed between plasma and 

 corpuscles; the lecithin, aboul <>.:! per cent, being twice ;i^ abundant in 

 corpuscles ;i> in plasma, and the cholesterol, 0.2 per cent, about equally 

 distributed. In diabetes ;ill of these substances arc seen to 1'" inc 

 in proportion to the severity of the disease, tin- increase l><'in<_ r mostly 

 in the plasma. The increase in cholesterol (confined mainly to tin' 

 plasma) is particularly interesting, since the substance is unaffected in 

 amounl 1».\ excessive feeding with fat. 



The Destination of the Fat of the Blood. In general, it may be said 

 that tlif blood fnt is transported to three places: 1 the depots for fat ; _' 

 tin' liver; and (3 the tissues. The fal present in each of these pli 

 differs from that in the others, as is revealed by chemical examination 

 by the methods described on page 687. The depot fat usually yields about 

 95 per cenl of its total weight as fattj acid. The I fat, nn the other 

 hand, yields only aboul 60 per cenl of its total weighl as fatty acid. 

 This difference indicates thai the fatty acid must 1 ombined in the 



tissues with a much larger molecule than is the case in the fat of the 



depots. This large molecule is probably that of lecithin or other pi 



pholipin, and the smaller molecule in the depots, that of neutral 



The liver fat takes an intermediate position between depot fat and ti- 

 fat in its yield of fatty acid. When no active metabolism of fat is 

 ing on. the liver fat is like that of the tissues-, luit when fat metabolism 

 is active, the liver fat occupies an intermediate position between 1 



fat and depot fat. 



