PAT METABOLISM 





liver is Pound to be infiltrated with fats, presumably to be handed on 

 elsewhere when worked up." It is interesting thai the fetus is greedy 

 of unsaturated fatty acids. 



The most likely soura of tin fat transported to tl>< liver is the fat 

 cut in the depots, unless when digestion is in | is, when it may l>c 



the fat from the intestine. That much of it comes from the depot 

 easily demonstrated. Thus, the more extensive the infiltration 

 liver -with fat, the inure closely will this fa1 1"' found to with the 



depot fat in its chemical characteristics. This has been very clearly 

 shown by, firsl of all, starving an animal so as to clear the dep fat 



as much as possible; then feeding it on some "ear-marked" fat (unusual 

 melting-point or a brominized fat); and after another day or bo of 

 starvation, so as to clear the liver itself of fat, poisoning the animal 

 with phosphorus or phlorhizin. The liver will be found shortly afl 

 wards to be invaded with fa1 which lias all the ear-marks of that on 



which the animal had been fed. 



Evidence <>f the same character has been furnished in a series of clin- 

 ical cases by observations on the amount of fat and 'he iodine value of 

 the fatty acid of the liver. This is shown in the ai mpanying table. 



r rn \' ros of Liver 



CAUSE OK r>F.\Tir 



Normal 



< '"inni.-li 



fatty 

 change 



cing 



1 . Pernicious anemia 



_'. Lobar pneumonia 



.".. Pernicious anemia 



I. Diab 



5. Toxemic jaundice 

 i\. Accident 



7. Empyema 



8. Phthisis 



This table clearly shows that the more fat there is in the liver, the 



nearer this fat approaches in character that Btored in the depots 

 That some of the fat -in the liver may come directly from t) 

 cently absorbed tfn intestim is also very readily demonstrable. 



Thus, when COCOanul oil was placed in the intestine Of anestl an- 



imals, along with bile salts and glycerine, it was found by Raper*' that 

 ::n per emit of the absorbed oil appeared in the livi 



