BY DR. KLEIN. 21 



be witnessed in any corpuscle of the kind we have been 

 studying. 



2. Granular Corpuscles. Of the three kinds of pale cor- 

 puscles which, as before stated, are to be observed in the blood 

 of the newt, we have now to consider the granular cells. These 

 are larger, but much less numerous than the others, and are 

 distinguished by the large dark granules they contain. To 

 observe them we must make a fresh preparation, for they un- 

 dergo changes of form much more -rapidly than the others. 

 The granular corpuscle is at first spheroidal. Very soon its 

 surface exhibits round and entirely hyaline prominences, into 

 which, however, granules appear shortly to find their way. 

 So long as the corpuscle presents this appearance, the only 

 changes of form observable consist in heaving movements of the 

 prominences. Eventually, one of these suddenly shoots out 

 into a prong-like process, into which the granular mass of the 

 original cell flows. Soon the corpuscle throws out a second 

 similar process, into which the mass again gathers itself, and 

 in this way advances across the field, with more or less ra- 

 pidity. After this has gone on for a certain time the move- 

 ments change their type : the corpuscle lengthens itself out 

 into a thread, in which the movement of the protoplasm is 

 rendered visible by that of the dark granules which it contains. 

 The thread swells out at the end into a little mass, from and 

 towards which alternately the rolling motion of the granules 

 is seen to be directed. Often a granular corpuscle may be ob- 

 served to creep about among groups of colored blood-disks, 

 stretching out its process with the terminal knob, as if this were 

 a feeler. In other cases we may witness the whole series of 

 changes described in the preceding paragraph as occurring in 

 the ordinary form of colorless blood corpuscle ; the main 

 difference being that the transformations are accomplished 

 within shorter periods. Finally, it may be noticed that in 

 granular cells, even when they are spheroidal, the nuclei often 

 show themselves as ovoid spaces free from granules. They 

 are, however, much more readily distinguished after the cell 

 has undergone changes of form. 



3. Colorless Corpuscles of the third form. In addi- 

 tion to the common colorless corpuscles and the granular cells 

 we have just had under observation, we notice a considerable 

 number of colorless elements of a different character. These 

 are of three kinds : (a) Small, well-defined bodies, resembling 

 nuclei, which retain only for a very short time the spheroidal 

 form which they had at first ; (b) larger corpuscles, consisting 

 of finely granular protoplasm, with jagged outline, containing 

 three or four distinct nuclei, which may be either roundish, or 

 flattened against each other, exhibit a double contour, and 

 contain a few fine nucleoli which are relatively of a large size, 



