36 THE EQUINE HOSPITAL FORMULARY. 



with another colleague (Mr. Hillyard), took the greatest 

 possible interest in watching our proceedings. 



'A dog, the first subject of our experiments, was bitten 

 at about 12 minutes to 10 o'clock a.m. on a certain day, by 

 a pufF-adder four times, every time in a different place. 

 The first three bites were with the same fang, the fourth 

 with the other fang. The first bite was on the nose. The 

 wound bled at once. The second bite, which was not a 

 very successful one, was near the seat of the first. The 

 third was on the shoulder, and the fourth, through the ear, 

 with the other fang (the right), bled a little. 



' Immediately after the first bite the animal gave utter- 

 ance to a distinct moan, as though aware of the sad fate to 

 which, in the interests of science, it had been decided to 

 consign him. Let me add here that the dog, though suf- 

 ficiently strong, in our opinion, to give us a trustworthy 

 train of symptoms, was not in such a condition as to live 

 with very great pleasure to himself. About five minutes 

 after the first bite the animal's nose began to swell very 

 noticeably. The following notes were taken by M. Perin- 

 guey, Mr. Hillyard and myself : 



'At 9.55 a.m. — The dog is getting very restless and 

 agitated. The nose has swollen to twice its natural size. 



' At 10 a.m. — The bite on the ear has had no apparent 

 effect — i.e., there is no discernible swelling. A foamy, 

 frothy secretion issues from the nostrils. The dog still 

 takes food. 



' At 10.5 a.m. — The swelling of the nose increases. The 

 dog becomes somewhat drowsy. 



' At 10.10 a.m. — The swelling, which is rather hard, has 

 extended from the upper lips as far as the eye ; but any 

 marked tumefaction has not made its appearance in the 

 other seats of injury. 



