74 POISONOUS PROTEINS 



sensitized animal. Similar results have been 

 obtained by dialysis methods by Pfeiffer and 

 Mita, by Pf eiffer and Jarisch, and by Zunz and 

 Gyorgy. The last mentioned have apparently 

 shown a marked increase in amino acids during 

 anaphylactic shock. This controverts the find- 

 ing of Auer and Van Slyke. 



I have repeatedly found, as others have, that 

 the blood serum shows sensitization for rela- 

 tively a short time, while the animal remains in 

 a sensitized condition much longer. This ob- 

 servation has convinced me that protein sensiti- 

 zation is accompanied by and is due, in some in- 

 stances at least, to a profound and lasting im- 

 pression made on the cells of the body. Indeed, 

 there can be no doubt that protein sensitization 

 is cellular. Pearce and Eisenbrey bled a sensi- 

 tized dog into a fresh one and at the same time 

 replaced the blood taken from the sensitized 

 one by that of a second fresh one. The sensi- 

 tized dog from which all its blood had been re- 

 moved responded with anaphylactic shock on 

 reinjection, while the dog now carrying all the 

 blood of the sensitized one did not. 



