PROTEIN FEVER 77 



quency of the doses. In 1909 my students and 

 I showed that by regulating the amount and 

 frequency of the dosage we could induce any 

 desired form of fever, acute, fatal, intermit- 

 tent, remittent or continued. 



Inasmuch as I have given elsewhere* the de- 

 tails of this work I will only reproduce the con- 

 clusions and make a few general remarks: (1) 

 Large doses of unbroken protein administered 

 intraabdominally, subcutaneously or intrave- 

 nously have no effect on temperature, at least 

 do not cause fever. (2) Small doses, especially 

 when repeated, cause fever, the forms of which 

 may be varied at will by changing the size and 

 frequency of the dosage. (3) The effect of pro- 

 tein injections on the temperature is more 

 prompt and marked in sensitized than in fresh 

 animals. (4) The intravenous injection of 

 laked blood corpuscles from either man or the 

 rabbit causes in the latter, even in small quan- 

 tity, either in single or repeated doses, prompt 

 and marked elevation of temperature. (5) 

 Laked corpuscles after removal of the stroma 

 by nitration have a like effect. (6) Protein fe- 

 ver can be continued for weeks by repeated in- 

 jections, giving a curve which cannot be dis- 

 tinguished from that of typhoid fever. (7) Pro- 



*Protein Split Products in Relation to Immunity and Disease, Lea & 

 Febiger, 1913. 



