78 POISONOUS PROTEINS 



tein fever is accompanied by increased nitrogen 

 elimination and gradual wasting. (8) Protein 

 fever includes most instances of clinical fever. 

 (9) Animals killed by experimentally induced 

 fever may die at the height of the fever, but 

 as a rule the temperature falls rapidly before 

 death. (10) Fever induced by repeated injec- 

 tions of bacterial proteins and ending in re- 

 covery may be followed by immunity. (11) The 

 serum of animals in which protein fever has 

 been induced digests the homologous protein in 

 vitro. In view of recent work on antiferment 

 in blood serum this point needs reinvestigation. 

 (12) Fever is one of the results of the parenteral 

 digestion of proteins. (13) There are two kinds 

 of parenteral proteolytic enzymes, one specific 

 and the other nonspecific. (14) The production 

 or activation of the nonspecific ferment is easily 

 and quickly stimulated. (15) The development 

 of the specific ferment requires a longer time. 

 (16) Sensitization and lytic immunity are dif- 

 ferent manifestations of the same process. (17) 

 Foreign proteins, living or dead, formed or in 

 solution, when introduced into the blood soon 

 diffuse through the tissues and sensitize the 

 cells. Different proteins have predilection 

 places in which they are deposited and where 

 they are, in large part at least, digested, thus 



