262 DISEASES OF TUB PAKENCHYMA OF THE LUNG. 



11. P. 192. 



Veratrin shows its effect upon the pulse often after the first 

 dose or two ; upon the temperature its action is more tardy, and is 

 often incomplete. The full effect is obtained, on an average, in 

 about eight or twelve hours ; but the premature occurrence of vom- 

 iting, prostration, and slowness of the pulse often compels suspen- 

 sion of the drug (which requires constant watching) before its anti- 

 febrile action has been gained. On the next day, if, as usually 

 happens, the influence of the veratrin has subsided, it may be 

 resorted to again, and perhaps even a third time, when a smaller 

 number of doses will answer the purpose. Veratrin is adapted 

 to pneumonia in robust subjects in whom the fever runs high 

 and hepatization is not far advanced. In asthenic cases it is best 

 avoided. 



In the latter class of cases quinine is a far preferable antipyretic, 

 since it cannot induce collapse. In order, however, to bring about 

 the desired remission or intermission of ten or fifteen hours, very 

 large doses must be given 1 to 2% grm. for adults, and 10 c. gr. for 

 each year of age in children, to be taken all at once or within one 

 hour. Such a dose need not then be repeated for forty-eight hours. 

 Liebermeister declares that in fevers marked by strong natural 

 remissions or intermissions quinine is much less strongly indicated 

 than in a continued or sub-continued fever, because by the tem- 

 porary artificial lowering of the temperature the danger of a con- 

 tinued high fever is reduced. There is some warrant for the belief 

 that both quinine and veratrin, by keeping down the temperature, 

 may actually curtail the inflammatory process in some moderate 

 pneumonias. 



12. P. 214. 



Inoculations upon the lower animals have been made by Villemin 

 and others, in order to test the infectious nature of tubercle. They 

 have settled unquestionably that yellow or gray tubercle, and caseous 

 matter from pneumonia and from degenerated lymph-glands, inject- 

 ed into the blood-vessels of Guinea-pigs and rabbits, cause in them 

 a development of fresh tubercle. Hence, in this sense, consumption 

 is infectious. A further experimentation with a great variety of 

 substances shows, however, that upon the injection of pus, of mis- 

 cellaneous dead animal matter, of blotting-paper, gutta-percha, cork, 

 sponge, quicksilver, or charcoal, miliary nodules would also form. 

 Thus it seems that miliary tubercle is not the characteristic mark 

 of a specific disease, but that a distinction is to be made between 

 tubercle as the product of simple inflammation and tubercle as depend- 



