ADDITION TO THE REVISED EDITION OF 1880. 767 



Since then numerous similar observations have shown circum- 

 scribed or extensive medullary infiltrations in the subserous and 

 intermuscular connective tissue, in the retina, etc. These seem 

 partly due to wandering of white blood-corpuscles, partly to actual 

 formation of lymphatic gland-tissue. Virchow suspects that the 

 colorless elements are the vehicles of the blood-dyscrasia, and that 

 they carry a contagious substance which excites the same develop- 

 ment wherever it lodges ; but Moslems experiments in transfusing 

 leuchaemic blood into healthy animals were negative. 



Nearly allied to leuchaemia is pseud oleuchaemia, HodgJcin's dis- 

 ease, adenie (Trousseau), anaemia lymphatica, malignant lymphosar- 

 coma. This disease, whose causes are entirely unknown, occurs both 

 in adults and children ; it has the same changes in the spleen and 

 lymphatic glands as true leuchsemia, but in the blood the red cor- 

 puscles are diminished without the white being increased. In this 

 disease also lymphatic new formations have been found in the se- 

 rous membranes, liver, and lungs. 



In a patient with splenic leuchaemia Mosler found excessive sen- 

 sitiveness of the sternum, so that it could not be touched or per- 

 cussed on account of the pain induced ; autopsy showed this to be 

 due to leuchaemic disease of this bone, as there was of the entire 

 skeleton. 



LeuchaBmia and pseudoleuchaemia probably have the same causes. 

 Whether these be located in the lymphatic organs or due to some 

 constitutional anomaly, they are of equally bad prognosis. 



TREATMENT, although generally considered of no avail, may be 

 of some good in the earlier stages. When there is any apparent 

 connection between the disease and the female sexual organs, ma- 

 laria, or syphilis, causal treatment may be tried. In enlarged spleen 

 large doses of quinine (ten to fifteen grains daily in acid solution) 

 may be useful, as they even reduce the size of the spleen in dogs 

 when it has enlarged as a result of division of the nerves. The 

 quinine may be aided by electricity and cold douches. For the 

 lymphatic tumors we may try injections of tincture of iodine, or 

 of iodine gr. in glycerin, and water in, xij, or ergotin gr. v in 

 glycerin and water, injected hypodermically. Iron may be given 

 in hopes of hastening the transformation of white into red cor- 

 puscles. Subcutaneous injections of defibrinated blood have also 

 been recommended. The treatment at present most relied on is by 

 arsenic internally and subcutaneously. 



END OF VOLUME I. 



