790 CHRONIC INFECTIOUS DISEASES. 



charged The eruption of nodules is attended by a nasal catarrh, 

 which is very intense around the ulcers, and is at first accompanied by 

 a thin transparent secretion. The discharge subsequently becomes 

 thick, tenacious, and purulent; and when the ulceration is far ad- 

 vanced, it is discolored by the admixture of blood, and becomes acrid 

 and fetid, and contains the debris of the necrosed tissues. 



In farcy, a disease which develops in the skin and lymphatics of 

 horses and similar animals, the tumors are larger than the genuine 

 tubercles of glanders. They contain a greater quantity of caseous mat- 

 ter, are discrete, or else congregate in clusters, or chains and wreaths. 

 After bursting, they form rounded ulcers, with elevated or everted 

 edges, with a foul, irregular bottom, furnishing a profuse ichorous dis- 

 charge, which often glues the surrounding hairs together, drying up 

 with them into hard crusts. 



Both glanders and farcy appear in man. The latter form, however, 

 is the more common, and usually attacks the skin, upon which it gen- 

 erally produces an eruption of tubercles, which are larger and more 

 numerous than those occurring in brutes. The lesions of the nasal 

 mucous membrane are exactly like those found in the horse. Those 

 of the skin, subcutaneous areolar tissue, muscles, and lungs, are puru- 

 'lent rather than caseous; so that in the skin they look like pustules, 

 and in the connective tissue, muscles, and lungs, they bear a great 

 similarity to metastatic abscesses. The lymphatics and their glands 

 are likewise often implicated in the disease in man, and, as in horses, 

 they sometimes produce a chain of farcy-buttons. An inflammation 

 not unfrequently extends from the lymphatics to the neighboring skin, 

 which thus becomes the seat of a malignant erysipelas, with a ten- 

 dency to gangrene. 



SYMPTOMS AND COURSE. The period of incubation of glanders or 

 farcy is of very variable duration. Where the virus has been im- 

 planted upon a wound, the first symptoms generally appear within 

 three or four days ; but, when infection occurs where there has been 

 no breach of surface (as when the virus is inhaled), the malady often 

 does not break out for months. The course and magnitude of glan- 

 ders also differ in the two cases. When the poison acts upon an 

 abrasion, the first symptoms which appear are usually local ; the 

 wound inflames ; the lymphatics of the part form knotted chains, and 

 their glands swell painfully. The inflammation assumes an erysipela 

 tous character, and is attended by an intense oedema. Blebs form, 

 and pustules, having discolored ichorous contents, and sometimes real 

 gangrenous bullae, arise upon the skin, and abscesses often develop, or 

 diffuse phlegmonous destruction takes place in parts about the in- 

 flamed lymphatics. Sometimes the disease seems to go no further 



