70 RINDERPEST, 



1. Animals having had the Rinderpest three to four years pre- 

 viously, cannot be infected again. 



.2-3. Vaccination in the first generation (taken from diseased ani- 

 mals), on sound cattle, after they have passed through the disease, frees 

 them from further infection. 



4. The loss by first generation is too large to recommend itself. 



5. The vaccine can be mitigated by second generation, producing 

 only a slight affection. 



6. This slight affection is also a preservative against new infection. 



I. Vaccination in older animals often fails, probably because they 

 have had it. 



8. Vaccination sometimes does not take, and yet they take the 

 plague naturally afterwards. 



9. Some cattle show no symptoms of disease after vaccination, and 

 yet they seem to be proof against infection. 



10. Well preserved vaccine keeps good for a few days, even in hot 

 slimmer. 



I I. It is yet to be discovered on which day of the disease to take 

 the virus, to get its full power. 



12. The tears, even diluted with distilled water, remain infectious 

 (these and the nasal mucus having been used for vaccination). 



To these may be added other conclusioDS arrived at by 

 Gamgee, who obtained 40 per cent of recoveries in experi- 

 ments by inoculation in seventy-five cases, and who, besides 

 refusing to recommend this method as a preventive ; noticing 

 the aggravations resulting from cold, wet and exposure; 

 declaring the means adopted for cultivating or modifying the 

 virus unsatisfactory and unreliable ; and any liquid from the 

 body of a sick animal capable of becoming a medium for 

 inoculation, adds : 



1. The cutaneous eruption not constant in natural Rinderpest is 

 usually seen in inoculated animals. 



2. Sheep can be inoculated from cattle, and again cattle from sheep, 

 without modifying the virulence of the virus. 



3. Glycerine modifies and then destroys the virus, as in the case of 

 pleuro-pneumonia (typhoid ?) 



4. Animals escaping after inoculation, without indicating the 

 characteristic symptoms, are not protected from future attacks. 



5. The produce from progeny of animals which have had the 

 Rinderpest, is as susceptible to an attack as any other.* 



* Cattle Plague, pp. 198 and 199. 



