SIXTH ANNUAL REPORT. 113 



In these animals all the viscera except the colon were free 

 from gross lesions, but in each instance the body showed many 

 indications of the profound exhaustion which terminated the dis- 

 ease. Microscopic examination of the heart showed an acute 

 fatty degeneration of the myocardium ; the liver and kidneys 

 exhibited the same pronounced change. 



The mucosa of the stomach and small intestine, though par- 

 taking somewhat of the general anaemic condition, were prac- 

 tically normal, and the small amount of food found in these tubes 

 was apparently in a natural condition of digestion. In the lower 

 part of the ilium fairly well-formed fecal masses were found ; 

 but, beginning with the caput coli, the conditions were entirely 

 changed, and the faeces were very fluid, flecked with blood, 

 mucus, and pus, and of a very foul odor. 



In the most severe case, that of " Rajah," the entire mucosa 

 of the colon was transformed into an almost continuous succes- 

 sion of large irregular ulcers. The ulcers showed raised, oede- 

 matous, undermined borders. The bases of the ulcers were 

 made up of a dark sloughing tissue, and a good many extended 

 down to the peritoneum; and, though none had macroscopically 

 perforated, the peritoneal surface of that portion of the gut was 

 covered with a recent septic exudate. 



Microscopic examination of sections of these ulcers showed 

 myriads of the parasites burrowing beneath the mucous mem- 

 brane, even along the lymphatic channels of the muscle coat and, 

 in places, as far down as the peritoneum. In some areas the 

 parasite was so abundant as to almost completely fill the field, 

 obscuring or displacing the tissues. 



Sections of mucosa, intervening between the ulcerations, 

 showed frequent Balantidia on the free surface, and small colo- 

 nies of from two to six or eight in the dilated bases of the crypts 

 of Lieberkiihn. 



The protoplasm of many of the parasites contained frequent 

 blood and epithelial cells, as well as detritus and numerous bac- 

 teria. Needless to say, the floors and sides of all the ulcers 

 showed bacterial infiltration, and the adenoid tissue was every- 

 where much inflamed. 



In the case of " Brunei," healing had begun in many of the 

 ulcers, and these were not as frequent as in the other animals. 

 The parasites were less numerous, and apparently the animal 



