106 PATHOLOGY. 



water, and a dilution of T^^^^jy^ produced. In the third glass, a 

 drop from the second gave a dilution of T.o^^.TyuTr- ^^ ^^^^ fourth 

 glass a drop of third dilution added to the 100 drops of water 

 produced a dilution of t7-5",o-d-o",o-(Jo- I^^ ^^^^ fifth glass, similarly 

 treated, there was a dilution of -ro,o"Troro o-o-.-tdd > ^^^ in the sixth 

 a drop of the dilution gave a trillionth (T:,-o(rij,waT),inj-o,-QoG)- 

 Matters being so disposed, four rabbits were inoculated respec- 

 tively with the first, second, third, and fourth dilutions, a horse 

 with the second, and a guinea-pig with the first. Next day all 

 the rabbits were dead, the guinea-pig fell ill, but recovered, and 

 the horse sustained no harm. M. Bouley communicated an 

 account to the Academie de Medicine of numerous experiments 

 he had made confirming the above, and stated that dogs can also 

 be killed by the septicemic virus derived from the rabbit, and 

 that such virus derived from the horse possesses much less 

 virulence than that furnished by the rabbit. 



I have repeatedly experimented on birds and rabbits with 

 the undiluted blood of pyosmic — septiccemic (Vogel) — rabbits 

 and birds, and have always induced death, either by a rapid 

 corruption of the whole blood-mass, from which the animals 

 have died in a few hours, or, resisting the first effects of the 

 morbid inoculated material, from pyaemia with abscesses in 

 various internal organs. 



Selecting mice as being specially adapted for experiments on 

 infective diseases, Koch has made some remarkable discoveries 

 pointing to the conclusion that death may be induced by (a) 

 a soluble poison, " Sepsin ; " by (b) a true septicpemia induced by 

 the multii)lication of the bacteria introduced by the inoculation ; 

 and by (c) a progressive destruction of tissue (gangrene), com- 

 mencing at the point of inoculation and spreading rapidly to 

 adjacent parts. 



Blood or meat infusion, which have putrefied for a short time, 

 act more injuriously than when putrefaction has extended over 

 a longer period, and five drops of such blood, if injected under 

 the skin of the back of a mouse, kills it within a short time. 

 There are marked symptoms of illness immediately after the 

 injection. The mouse becomes restless, runs about constantly, 

 but showing great weakness and uncertainty in all its move- 

 ments ; it refuses food, the respiration becomes irregular and 

 slow, and death takes place in from four to eight hours. 



