240 CONTAGIOUS DISEASES. 



was obtained from a farcy ulcer, and the disease appeared at the 

 precise point of the inoculating puncture. 



ACUTE GLANDERS. 



Symptoms. — The disease, preceded by increased temperature 

 of the body, appears suddenly, ushered in by rigors, some- 

 times of a most persistent character. In one case which fell 

 under my notice the rigors continued without intermission for 

 three days and nights, at the end of which time a sanguineous 

 discharge issued from both nostrils, the Schneiderian mucous 

 membrane became violently inflamed and deeply ulcerated. 

 More commonly, however, the rigors are not so persistent, but 

 they are always more or less observable ; the temperature is 

 sometimes as high as 106° or even 109° R, the breathing is 

 accelerated, the pulse feeble, rapid, and even dicrotonous, the 

 lieart's action palpitating and accompanied by metallic tinkling, 

 the appetite fails, the pituitary membrane, at first of a dark 

 copper colour, with patches of ecchymosis of a dark red hue, 

 becomes purple, and the patches are rapidly converted into pit- 

 like, ragged-edged ulcers, from which issues a copious sanious 

 discharge. The submaxillary lymphatic glands enlarge. Other 

 lymphatic glands inflame, enlarge, suppurate, burst, and expose 

 raw, unhealthy-looking sores, from which issues a more or less 

 ichorous and irritating purulent material. The eyes are weak, 

 and a discharge issues from them ; the nostrils are often swollen. 

 The breathing is hurried, irregular, and impeded by the swelling 

 of the nostrils, and by the glutinous discharge drying around 

 them ; abscesses speedily form along the course of the 

 lymphatics of the face. The urine is pale, watery, and increased 

 in quantity. 



Acute glanders is rapidly fatal, and the post mortem exami- 

 nation reveals the following lesions : — The mucous membrane 

 lining the nasal passages and facial sinuses is violently inflamed, 

 and covered with a numerous crop of pustules and rdcers, from 

 which a purulent or sanious fluid is freely discharged. In many 

 instances, and where the disease has been very rapid, the inflam- 

 mation is diffused over the whole surface of the mucous mem- 

 brane, which then presents one uniform purple or purplish-black 

 hue, its structure being exceedingly soft and friable from degene- 



