STOMATITIS rUSTULOSA CONTAGIOSA. 253 



The healing process commenced in the ulcers about the sixth 

 or eiglith days, and all the cases under treatment resulted in 

 the animals getting quite clear of the disease in from twelve 

 to fourteen days. 



Experiments as to the transmissibility of the disease by in- 

 oculation and infection were made on sixteen horses, two 

 cattle, four sheep, one goat, three swine, two dogs, one rabbit, 

 and five men, with varying results. Tour men and a number of 

 horses took the disease by natural contagion, independently of 

 experimental inoculation. 



Below are given a few extracts from the diary kept during 

 the course of the experiments. 



'12d May. — A seven months' old foal was successfully inocu- 

 lated on the dental surface of the lip, the left ear, and the internal 

 surface of the left fore leg ; the resulting eruption was extensive 

 and confluent, and the disease protracted, not having completely 

 ceased until the twenty-first day. 



'dQth May. — A healthy foal was placed with the above one, 

 and another was inoculated on the vaginal mucous membrane. 

 The inoculated one gave a negative result, but in the healthy 

 foal the result was positive, the disease running its course, and 

 terminating in eleven days. 



?>lst May. — Another horse was placed with the last-mentioned 

 foal. On the 2d of June nodules were formed, the disease 

 terminating on the 12th. Others were inoculated with similar 

 results, and the four foals which passed through all the stages 

 of the disease before were again inoculated, but did not become 

 infected a second time. One showed three small nodules, which 

 disappeared without ulcerating in a few days. 



24:th May. — A calf was inoculated on the vulva. No symp- 

 toms appeared, and it was again inoculated on the 30th, after 

 which the disease fully established itself, terminating in eight 

 days. Others were inoculated with similar results. 



22>d May. — Sheep were inoculated with negative results. In 

 pigs the result was also negative. In dogs, nodules appeared, 

 but no ulceration. Eabbits were not affected. 



2Wi May. — Mr. Hansel (student) inoculated himself. There 

 was redness and unpleasant itching and swelling of the part, the 

 formation of a pustule, over which a yellow-brownish crust formed, 

 which fell off in fourteen days, leaving a deep cicatrix. 



Other four gentlemen inoculated themselvps without infection. 



