QUARTEK-ILL. 309 



into the wound. If tlie operation be carefully performed, the 

 animal will have immunity conferred upon it. 



In many, for two or three days, there is dulness and dis- 

 inclination to feed, but this soon passes off, leaving no ill effects. 



But if the virus escapes into the wound, or if the animal has 

 any bruises upon it, there we may expect to see the tumour of 

 quarter-ill appearing, and death resulting. 



Others again, instead of using the virus direct, inoculate a 

 guinea-pig subcutaneously, and cause the formation of a tumour 

 containing germs, which are thus modified in their power, and 

 after mixing with water, triturating, and passing through muslin, 

 use it. Others again have used the dessicated virus prepared 

 by drying in air portions of the deceased tissues. We, however, 

 are of opinion that Cornevin, Arloing, and Thomas' method of 

 using the virulent tissue mixed with water and filtered as above 

 stated, is the best. 



Eor general use, the virus contained in the fluid and muscles 

 of the diseased parts are dried at a temperature of 89° to 95° F., 

 the dried mass is then powdered, mixed with water and boiled. 

 This is used as the first vaccine, and a second and stronger one is 

 obtained by heating to 176° F. only ; others use cultures, but, 

 as above stated, Arloing, Cornevin, and Thomas' is the most 

 convenient method. 



Many other methods of preventing this disease have been in 

 use from ancient times, and seemingly with success ; setoning, 

 for instance, when performed on young animals not affected 

 with the disease, but having been in contact with affected 

 animals, almost invariably is said to protect the animal for the 

 time being at least. We think that the setoning itself does not 

 protect, but that the dietetic and hygienic alterations which 

 accompany it materially tend to stop its progress, and the credit 

 is thus given to the wrons:; agent. 



