316 CONTAGIOUS DISEASES. 



fifth generation, then a sixth, a seventh, and an eighth genera- 

 tion. With this three animals were inoculated at different times, 

 All three animals became diseased in due time. 



" In order to correctly interpret the results of this last (sixth) 

 series of experiments, it is important to mention that inoculation 

 with dried lymph, diluted far less than would correspond to the 

 third generation in the last-named experiments, is ibllowed by 

 a negative result." 



MORBID AXATOJIY, 



In the majority of animals, the skin about the perineum, 

 groin, belly, and neck is swollen, and of a diffuse red or Ijluish- 

 red colour, and the ear lobes and the skin of the nose also red 

 and swollen, whilst in some instances there are gangrenous 

 patches of the superficial cutaneous structures. In many in- 

 stances, however, this redness of the skin may be entirely 

 absent, even after death ; but the longer the animal lives, the 

 superiicial structures become, as a rule, the more swollen, and 

 the dependent parts of the ears become deep red, puffy masses, 

 from the surface of which the epidermis peels off. 



The blood-vessels of the skin are more or less filled with blood 

 or plugged with fibrin, and around the vessels lymphoid cells 

 are discoverable ; the suderiporous glands are greatly distended, 

 and often filled with blood charged with large coarsely granular 

 cells containing large clear vesicular nuclei. The connective 

 tissue of the corium contains fibrinous exudations and a yellow 

 serosity. 



The small intestines almost invariably, and the stomach more 

 rarely, are congested and covered with spots of ecchymosis, both 

 upon their mucous and peritoneal surfaces. The large intes- 

 tines have always the most characteristic appearances. There 

 are isolated or confluent, generally roundish, ulcerations at and 

 around the ilio-csecal valve, the rest of the mucous membrane 

 being congested and studded with spots of ecchymosis. Klein 

 says the whole large intestine down to the rectum contains 

 ulcers ; in the crecum they are confluent, and measure several 

 inches, extending transversely as well as longitudinally ; while 

 the whole remaining mucous membrane of the large intestine 

 is much thickened, and in some parts the mucous tissue con- 

 tains large" accumulations of blood. The ulcers are of various 



