5G8 SPOEADIC DISEASES. 



itself, but by affording a cover and harbour for parasites, which 

 I think have been proved to be the source of enormous losses. 



With regard to the ked, Melophagus ovis, found upon all 

 sheep, and having no connection with the disease under con- 

 sideration, it was discovered that those removed from sheep 

 suffering from louping-ill contained the germs of the organism, 

 and that it could be cultivated as readily as that of the tick 

 itself, whereas, when it was removed from sheep healthy and 

 not upon louping-ill land, no results were obtained, although 

 several experiments were made. The fact that ticks induce 

 more diseases than loitping-ill is now fully recognised (see Texas 

 Fever). 



i'uKTHER Investigations, 1894-6. 



Louping-ill Inoculations at the College. 



1894, 

 May 2. Sheep inoculated at 3 "25 p.m. with cultivation from sheep killed at 

 Brown's farm, Dalmally, whilst suffering from louping-ill. Tempera- 

 ture 103° F. 



,, 3. Temperature 102° F. 



,, 4. Partial paralysis of the fore limbs; convulsive twitchings or "trem- 

 bling " ; foaming at the mouth. Temperature 102° F. 



,, 5. Complete paralysis of the fore limbs ; partial paralysis of the hind 

 limbs ; convulsive movements, &c. increased. Temperature 104° F. 



,, 6. Sheep died, 8 a.m. Post-mortem revealed louping-ill lesions. 



On the same day. May 2, from ten to fifteen living ticks were 

 placed on each of the remaining sheep, six in number. These 

 were examined on the following morning, when it was found 

 that the ticks had almost entirely disappeared ; they were re- 

 examined daily until June 2, and, giving no evidence of infec- 

 tion, all the ticks having evidently dropped off without becoming 

 adherent to the skin of the sheep, the following experiments 

 were made : — 



Inoculations with Cultivations from Ticks. 



June 2. Sheep No. 1 inoculated, 2 "30 p.m. Temperature 104 i° F. 



,, 3. Temperature 103° F. 



,, 4, Temperature 104° F. 



,, 5. Temperature 104° F. 



„ 6. Temperature 104° F. Results negative. 



,, 9. Sheep No. 2 inoculated, 2 p.m. Temperature 104*° F, 



,, 10. Temperature 105° F. 



