158 



THE VENOM OF HELODERMA. 



The hemolytic action of dog serum and venom upon turtle corpuscles is 

 quite variable. In cases in which large quantities of dog serum were added to 

 venom, the turtle corpuscles were partially hemolyzed, but the same quanti- 

 ties of dog serum alone also caused hemolysis, although slightly less marked. 



1 ex. of 5 per cent suspension of turtle corpuscles. 



In another experiment with corpuscles from another turtle in which dog 

 serum was combined with diminishing quantities of venom, no hemolysis took 



place. 



HORSE SERUM. 



Horse serum as well as dog serum serves as an activator for venom. The 

 action of venom and horse serum was tested upon guinea-pig, rabbit, and dog 

 corpuscles, with similar results in each case. Horse serum alone has distinctly 

 less hemolytic activity than dog serum, but it serves equally as well as an 

 activator for the heloderma venom. 



2 c.c. of 5 per cent suspension of guinea-pig corpuscles. 



TURTLE SERUM. 



Turtle serum, like horse and dog serum, activates the heloderma venom. 

 This was tested on rabbit and guinea-pig corpuscles. When venom was com- 

 bined with diminishing quantities of turtle serum these corpuscles showed 



1 c.c. of 5 per cent suspension 

 of rabbit corpuscles. 



1 c.c. of 5 per cent suspension 

 of turtle corpuscles. 



marked lysis. When the activating influence of turtle serum was tested with 

 turtle corpuscles no hemolysis occurred. Turtle corpuscles seem to be very 

 resistant to the combination of venom and turtle (or dog) serum. 



