ACTION OF CALMETTE S COBRA ANTIVENIN. 



203 



the neurotoxins as antigen, the antitoxin acting strongly on the neurotoxin 

 used as an antigen, and only very weakly upon the neurotoxin of a related 

 reptile. 



The recent experiment of Bang and Overton,* who found that the cobra 

 antitoxin had a protecting influence on tadpoles which were kept in a solution 

 of crotalus venom, to which the cobra antivenin had been added, seems to 

 point to a similar conclusion as that reached by ourselves. We must take into 

 consideration the fact that Bang and Overton observed the neutralizing effect 

 in experiments with crotalus venom, a substance rich in hemorrhagin; but per- 

 haps in this case also the protecting influence of the antivenin was mainly 

 directed against the neurotoxin in the crotalus venom. 



The following table gives a summary of our result : 



'Bang and Overton. Biochem. Zeitschrift, Bd. 34, p. 428, 1911. 

 fOnly one of these died. 



