144 NiiW ViJRK ZOOLOGICAL SOCIETY. 



philia accompanies such disturbance, one would naturally expect 

 a relative increase, at least in the eosinophilic cells. Though 

 this does not appear Im ])v the ease in the instances observed by 

 us, it is quite possible that in the earlier stages, when involvement 

 of the bone marrow begins the conditions may be present and 

 subsequently disappear. The gross appearances of the blood, in 

 terminal cases, exhibit the usual characteristics of extreme 

 anaemia and coagulation is oftentimes very much retarded. 



Muscles. — No definite alteration, which can be looked upon as 

 other than entirely secondar\-, has been found in the muscles. 

 There are no changes in those of the paralyzed extremities, except 

 a general wasting with fat absorption, though occasionally there 

 is a relative over-deposition of adipose. The muscle cells be- 

 come atrophied, but no nodes of disintegration or of nuclear pro- 

 liferation have been seen and the atrophy seems to be entirely 

 one of disuse, occasionally accompanied by a pressure-atrophy 

 following over-deposit of fat. The muscles away from the im- 

 mediately involved extremities show no changes, except such as 

 are entirely dependent on the secondary conditions induced by 

 the disease. No lesions of the smooth muscle distribution have 

 been found. 



Osseous System. — Disease of the bony tissue appears to us to 

 be the essential characteristic of the disorder and it is on these 

 changes that we classify the disease as osteomalacia, identical in 

 all its essential particulars with the condition so fully described 

 as it occurs in man and tln' domestic animals. 



All the bones of the body, even those of the skull, eventually 

 become involved. The changes are most obvious and deformity 

 most prominent in those bont-s wliirli may be looked upon as 

 the supporting frame-work of the Ijody; these are the bones of 

 the lower extremities, particularly the femurs, the spinal column 

 and those of the thoracic cage. l"he pelvis is relatively much 

 less deformed than in man. ]:)robably because the weight of the 

 I)ody is less suspendid on these bones in the monkeys, which 

 ordinarilv use the upi)cr extremities for the ])urposes of locomo- 

 tion, together witli the lowrr. W-ry ]il<cl\ it is for this same 

 reason that the thorax shows very early and mneli nKu-c j)ro- 

 nouncerl fleformities than is the cases in the human. 



One of the very earliest osseous deformities, consists in a l)i)w- 

 ing. usually a jjosterior kvphosis of llie spinal rolnnm. most 

 marked in the (lorsal region associated witli a in.ukrd h\ pcii n ipliv 

 of the lumbar and sacral vertebrae. Lateral d(\ i.iti' ms are. in 

 our experience, out of the ordinary. This deformity i^ quite as 



