150 XKW YORK ZOOI.OC.ICAL SOCIFTV. 



entirely iMcali/.cd t^. llir Inn^s and lliv adjaceiU lymph nodes, 

 from which a j^enrral infcclinn is very hkely to arise. 



Spleen and l.ynip/i Xodcs. — L'oni^estiiui and sometimes actite 

 hvperaeniia of these sirnelm"es is present. As a rnle, they are 

 more or los cnhir^cd. (hie to acute or chr<Mn'c Inperplastic 

 l_\inphadcnilis. 



Ihict/css Claniis. — I lie ilixroid i;hind shows no lesions, it is 

 apparently neither increased nor diminished in size. The thymus 

 hody shows no variations from the normal. The adrenal inlands 

 frequenth show coniiestion, with sli<.;ht fatty dei^eiicration of the 

 cortical cells. 



Urinary Tract. — '1 lu- kidiicx- ordinariK- shows more or less 

 congestion with fattv and parenchx inatous defeneration and occa- 

 sionally slitiht interstitial nephritis. The Ijladder exiiibits no 

 alterations and we have never found it to contain calcareous 

 deposit, as has been reported in occasional cases in man (Dock, 

 American journal of .Medical Sciences, p. 499, 1895 1. We have 

 not. as yet, studied the urine in these cases. 



Cicnital (Hands. — The disease has been found, in our cases, 

 most fre(|uent in males, even those presenting' the osseous lesions 

 supi)Osed to be characteristic of "true osteomalacia," and we are 

 therefore unable to state as to the relationship between the ovaries 

 and osteomalacia in the ])rimates, thoujuh the beariiij;' of the i)uer- 

 peral state and the de\elopment of the disease in man seems to 

 be well established. It is notewortln that the i)riniates cliieth- 

 aftected rarely re])roduce in ca|)tivitv or show anv marked sexual 

 prochvities. In so far as we have investit^'ated the disease, there 

 seems to be no palholi>j;ical changes ])resent in the ^I'liital glands 

 of either sex. 



Central Xcr:-on.s' Sy.s-tcin. — Changes in the central nervous sys- 

 tem are constant in the well-develo])ed sta.^es of the disease and 

 the symptoms arising- from this involvement of tlu' brain an(l 

 spinal cord are amoniii" the most characteristic of the conditions, 

 tendint;- to overshadow the osseous .alterat ii in<. rni])abl\ for this 

 reason the condition has been comnionh b ukrd npim as a piiinar\- 

 disease of the central nervous s\steni and it wa^ al'Mii; these lines 

 that we first undertook the study of the nialad\. In the li<;ht 

 of more recent observation it ai)i)ears to us that tlie usseous lesions 

 jjreccde thf>se of the central nervous organs, which are j^robably 

 sccondarx-. thou.y;h we must not forget that some observers still 

 look upon the osteomalacia as a tro])ho-neiirosis (I'lhlin^': see 

 Mallaril. '■Osteomalacic a fornu' ner\eusc."" Ihil. .Sdc. nied. d. 

 ho]). dc Lyon. I9n_:^. 11 ). It d< ts not appear at all stranm'e that 



