NINTH ANNUAL REPORT. 165 



tirely cartilaginous. Lumbar vertebrae enlarged, softened, and 

 showing quite extensive anterior curvature. 



Blood Examination (specimen taken from ear, just before ani- 

 mal was killed). — Haemoglobin 65 per cent (Dare). On draw- 

 ing the blood it was found to be abnormally light in color and to 

 flow very slowly, being of a somewhat gelatinous consistency like 

 the blood in leuchaemia. It clotted rapidly, but the resulting clot 

 was not so firm and compact as normal. 



The red cells are found to vary greatly in size, many microc}1:es 

 and macrocytes being present. Poikilocytes are numerous, but 

 no degenerated cells were found. A few normoblasts were found 

 and a few megaloblasts. Blood plates are very numerous. Leu- 

 cocytes are found to be relatively very frequent, a few of them 

 are pigmented, and one very large mononuclear leucocyte was 

 found. The differential leucocyte count shows : 



Polynuclear neutrophiles 67.0 per cent. 



Lymphocytes ■. . . 27.5 



jMononuclears 0.5 " 



Transitionals 3.0 " " 



Eosinophiles i.o " " 



Basophiles i .0 " " 



The granules in the eosinophilic cells are notablv smaller than 

 in man, otherwise the cells do not appear to differ much from 

 those found in the human. 



Bone Marroiv (Smear). — Many abnormal cells are present. 

 Giant cells, for the greater part polynuclear, with eosinophilic 

 granulation are numerous. In some of them a typical karyokinesis 

 is demonstrable while large megaloblasts showing almost any 

 stage of karyokinesis are not infrequent. Dividing normoblasts 

 are common. Notable is the large number of leucocytes with 

 basophilic granulation, the granules being notably smaller than in 

 man. Phagocytic cells, leucocytes and giant cells are very com- 

 mon. Many of the erythrocytes present show very extreme de- 

 generative alterations and free pigment granules are commonly 

 found. 



MICROSCOPIC EXAMIX.XTIOX. 



Cervical Cord. — The membranes of the cord show nothing 

 abnormal. There is slight irritation of the perivascular and peri- 

 cellular lymph spaces and some of them contain slight exudation 

 of small round cells. The ganglion cells of the atitcrior horns 

 show no alteration. Segments jjreparcd by the Rusch niodifica- 



